A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Thioguanine Overdose, Contraindications and Information - Thioguanine
Thioguanine Overdose, Contraindications and Information - Thioguanine
OVERDOSE
Signs and symptoms of overdosage may be immediate, such as
nausea, vomiting, malaise, hypotension, and diaphoresis; or delayed, such as
myelosuppression and azotemia. It is not known whether thioguanine is dialyzable.
Hemodialysis is thought to be of marginal use due to the rapid intracellular
incorporation of thioguanine into active metabolites with long persistence.
The oral LD50 of thioguanine was determined to be 823 mg/kg ± 50.73
mg/kg and 740 mg/kg ± 45.24 mg/kg for male and female rats, respectively. Symptoms
of overdosage may occur after a single dose of as little as 2.0 to 3.0 mg/kg
thioguanine. As much as 35 mg/kg has been given in a single oral dose with reversible
myelosuppression observed. There is no known pharmacologic antagonist of thioguanine.
The drug should be discontinued immediately if unintended toxicity occurs during
treatment. Severe hematologic toxicity may require supportive therapy with platelet
transfusions for bleeding, and granulocyte transfusions and antibiotics if sepsis
is documented. If a patient is seen immediately following an accidental overdosage
of the drug, it may be useful to induce emesis.
CONTRAINDICATIONS
Thioguanine should not be used in patients whose disease has
demonstrated prior resistance to this drug. In animals and humans, there is
usually complete cross-resistance between PURINETHOL (mercaptopurine) and TABLOID
brand Thioguanine.
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