Terra-Cortril Pharmacology, Pharmacokinetics, Studies, Metabolism - Oxytetracycline and Hydrocortisone

Terra-Cortril Pharmacology, Pharmacokinetics, Studies, Metabolism - Oxytetracycline and Hydrocortisone

CLINICAL PHARMACOLOGY

PHARMACOLOGICAL ACTION

Oxytetracycline is a product of the metabolism of Streptomyces rimosus and is one of the family of tetracycline antibiotics. It is primarily bacteriostatic and is thought to exert its antimicrobial effect by the inhibition of protein synthesis.

Oxytetracycline is effective against a wide range of gram-negative and gram-positive organisms.

Polymyxin B sulphate is one of a group of related antibiotics derived from Bacillus polymyxa.

It is rapidly bactericidal but exclusively against gram-negative organisms .

It is particularly effective against Pseudomonas aeruginosa and Haemophilus aegyptius (Koch-Weeks bacillus) frequently found in local infections of the eye and ear.

Hydrocortisone acetate is a corticosteroid with anti-inflammatory, anti-pruritic and vasoconstrictive actions.