Temodar Overdose, Contraindications and Information - Temozolomide

Temodar Overdose, Contraindications and Information - Temozolomide

OVERDOSE

Doses of 500, 750, 1,000 and 1,250 mg/m² (total dose per cycle over five days) have been evaluated clinically in patients. Dose-limiting toxicity was hematologic and was reported at 1,000 mg/m² and at 1,250 mg/m². Up to 1,000 mg/m² has been taken as a single dose, with only the expected effects of neutropenia and thrombocytopenia resulting. In the event of an overdose, hematologic evaluation is needed. Supportive measures should be provided as necessary.

CONTRAINDICATIONS

TEMODAR (temozolomide) Capsules are contraindicated in patients who have a history of hypersensitivity reaction to any of its components. TEMODAR is also contraindicated in patients who have a history of hypersensitivity to DTIC, since both drugs are metabolized to MTIC.