A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Temodar Online, Description, Chemistry, Ingredients - Temozolomide
Temodar Online, Description, Chemistry, Ingredients - Temozolomide
DESCRIPTION
TEMODAR (temozolomide) CAPSULES
TEMODAR Capsules for oral
administration
contain temozolomide, an imidazotetrazine derivative. The chemical
name of temozolomide is 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-as-tetrazine-8-carboxamide.
The material is a
white to light
tan/light pink powder
with a molecular formula of C6H6N6O2
and a molecular weight of 194.15. The molecule
is stable at acidic pH
< 5, and labile at pH> 7, hence can be administered orally.
The prodrug, temozolomide, is rapidly hydrolysed to the active 5-(3-methyltriazen-1-yl)
imidazole-4-carboxamide (MTIC) at neutral
and alkaline pH
values, with hydrolysis
taking place even faster at alkaline
pH.
Each capsule contains
5 mg, 20 mg, 100 mg, or 250 mg
of temozolomide. The inactive ingredients for TEMODAR CAPSULES are
lactose anhydrous,
colloidal silicon dioxide, sodium
starch glycolate, tartaric
acid, and stearic acid.
Gelatin capsule shells
contain titanium dioxide.
The capsules are imprinted with pharmaceutical
ink.
TEMODAR 5 mg: green
imprint contains pharmaceutical
grade shellac, anhydrous
ethyl alcohol,
isopropyl alcohol, n-butyl
alcohol, propylene glycol,
ammonium hydroxide,
titanium dioxide, yellow
iron oxide
and FD&C Blue #2 aluminum
lake.
TEMODAR 20 mg: brown imprint also contains pharmaceutical
grade shellac, anhydrous
ethyl alcohol,
isopropyl alcohol, n-butyl
alcohol, propylene glycol, purified water, ammonium
hydroxide, potassium
hydroxide, titanium dioxide, black
iron oxide, yellow
iron oxide, brown iron
oxide, and red iron
oxide.
TEMODAR 100 mg: blue
imprint contains pharmaceutical
glaze (modified) in an ethanol/shellac mixture, isopropyl alcohol,
n-butyl alcohol, propylene glycol, titanium
dioxide, and FD &C Blue #2 aluminium lake.
TEMODAR 250 mg: black, imprint contains pharmaceutical
grade shellac, anhydrous
ethyl alcohol,
isopropyl alcohol, n-butyl
alcohol, propylene glycol, purified water, ammonium
hydroxide, potassium
hydroxide, and black iron
oxide.
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