A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tazorac Side Effects, and Drug Interactions - Tazarotene
Tazorac Side Effects, and Drug Interactions - Tazarotene
SIDE EFFECTS
In human dermal safety studies, tazarotene 0.05% and 0.1% gels
did not induce allergic contact sensitization, phototoxicity or photoallergy.
Psoriasis:
The most frequent adverse events reported with TAZORAC®
Gel 0.05% and 0.1% were limited to the skin. Those occurring in 10 to 30% of
patients, in descending order, included pruritus, burning/stinging, erythema,
worsening of psoriasis, irritation, and skin pain. Events occurring in 1 to
10% of patients included rash, desquamation, irritant contact dermatitis, skin
inflammation, fissuring, bleeding and dry skin. Increases in "psoriasis
worsening" and "sun-induced erythema" were noted in some patients
over the 4th to 12th months as compared to the first three months of a 1 year
study. In general, the incidence of adverse events with TAZORAC®
Gel 0.05% was 2 to 5% lower than that seen with TAZORAC® Gel
0.1%.
Acne:
The most frequent adverse events reported with TAZORAC®
Gel 0.1% in the treatment of acne occurring in 10 to 30% of patients, in descending
order, included desquamation, burning/stinging, dry skin, erythema and pruritus.
Events occurring in 1 to 10% of patients included irritation, skin pain, fissuring,
localized edema and skin discoloration.
DRUG INTERACTIONS
Concomitant dermatologic medications and cosmetics that have
a strong drying effect should be avoided. It is also advisable to "rest" a patient's
skin until the effects of such preparations subside before use of TAZORAC®
Gel is begun.
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