Talwin Compound Pharmacology, Pharmacokinetics, Studies, Metabolism - Pentazocine and Aspirin

Talwin Compound Pharmacology, Pharmacokinetics, Studies, Metabolism - Pentazocine and Aspirin

CLINICAL PHARMACOLOGY

Pentazocine is a potent analgesic which when administered orally is approximately equivalent, on a mg for mg basis, in analgesic effect to codeine. Two caplets of TALWIN Compound when administered orally have the additive analgesic effect equivalent to 25 mg of TALWIN plus 650 mg of aspirin. TALWIN Compound provides the analgesic effects of pentazocine and the analgesic, anti-inflammatory, and antipyretic actions of aspirin.

Onset of significant analgesia usually occurs between 15 and 30 minutes after oral administration, and duration of action is usually three hours or longer. Onset and duration of action and the degree of pain relief are related both to dose and the severity of pretreatment pain. Pentazocine weakly antagonizes the analgesic effects of morphine, meperidine, and phenazocine; in addition, it produces incomplete reversal of cardiovascular, respiratory, and behavioral depression induced by morphine and meperidine. Pentazocine has about ¹ / ₅₀ the antagonistic activity of nalorphine. It also has sedative activity.