A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cognex Online, Description, Chemistry, Ingredients - Tacrine
Cognex Online, Description, Chemistry, Ingredients - Tacrine
DESCRIPTION
Cognex® (tacrine hydrochloride) is a reversible cholinesterase inhibitor, known
chemically as 1,2,3,4-tetrahydro-9-acridinamine monohydrochloride monohydrate.
Tacrine hydrochloride is commonly referred to in the clinical and pharmacological
literature as THA. It has an empirical formula of C 13 H 14
N 2 ·HCl·H 2 O and a molecular weight of 252.74.
Tacrine hydrochloride is a white solid and is freely soluble in distilled water,
0.1N hydrochloric acid, acetate buffer (pH 4.0), phosphate buffer (pH 7.0 to
7.4), methanol, dimethylsulfoxide (DMSO), ethanol, and propylene glycol. The
compound is sparingly soluble in linoleic acid and PEG 400.
Each capsule of Cognex® contains tacrine as the hydrochloride. Inactive ingredients
are hydrous lactose, magnesium stearate, and microcrystalline cellulose. The
hard gelatin capsules contain gelatin, NF; silicon dioxide, NF; sodium lauryl
sulfate, NF; and the following dyes: 10 mg: D&C Yellow #10, FD&C Green
#3, titanium dioxide; 20 mg: D&C Yellow #10, FD&C Blue #1, titanium
dioxide; 30 mg: D&C Yellow #10, FD&C Blue #1, FD&C Red #40, titanium
dioxide; 40 mg: D&C Yellow #10, FD&C Blue #1, FD&C Red #40, D&C
Red #28, titanium dioxide.
Each 10-, 20-, 30-, and 40-mg Cognex® capsule for oral administration contains
12.75, 25.50, 38.25, and 51.00 mg of tacrine HCl, respectively.
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