A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Chemet Indications, Dosage, Storage, Stability - Succimer
Chemet Indications, Dosage, Storage, Stability - Succimer
INDICATIONS
AND USES
CHEMET is indicated for the treatment of lead poisoning in pediatric patients
with blood lead levels above 45 µg/dL. CHEMET is not indicated for prophylaxis
of lead poisoning in a lead-containing environment; the use of CHEMET should
always be accompanied by identification and removal of the source of the lead
exposure.
DOSAGE AND ADMINISTRATION
Start dosage at 10 mg/kg or 350 mg/m 2 every eight hours for five
days. Initiation of therapy at higher doses is not recommended. (See Table II
for Dosing chart and number of capsules.) Reduce frequency of administration
to 10 mg/kg or 350 mg/m 2 every 12 hours (two-thirds of initial daily
dosage) for an additional two weeks of therapy. A course of treatment lasts
19 days. Repeated courses may be necessary if indicated by weekly monitoring
of blood lead concentration. A minimum of two weeks between courses is recommended
unless blood lead levels indicate the need for more prompt treatment.
TABLE II
CHEMET (SUCCIMER) PEDIATRIC DOSING CHART
| LBS |
KG |
DOSE (MG) * |
Number of
CAPSULES * |
| 18-35 |
8-15 |
100 |
1 |
| 36-55 |
16-23 |
200 |
2 |
| 56-75 |
24-34 |
300 |
3 |
| 76-100 |
35-44 |
400 |
4 |
| >100 |
>45 |
500 |
5 |
| * To be administered every 8 hours for 5 days, followed
by dosing every 12 hours for 14 days. |
In young pediatric patients who cannot swallow capsules, CHEMET can be administered
by separating the capsule and sprinkling the medicated beads on a small amount
of soft food or putting them in a spoon and following with fruit drink.
Identification of the source of lead in the pediatric patient's environment
and its abatement are critical to a successful therapy outcome. Chelation therapy
is not a substitute for preventing further exposure to lead and should not be
used to permit continued exposure to lead.
Patients who have received CaNa 2 EDTA with or without BAL may use
CHEMET for subsequent treatment after an interval of four weeks. Data on the
concomitant use of CHEMET with CaNa 2 EDTA with or without BAL are
not available, and such use is not recommended.
HOW SUPPLIED
100 mg capsules in bottle of 100 (NDC 67386-201-11)
Storage
Store between 15°C and 25°C and avoid excessive heat.
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