A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Streptomycin Side Effects, and Drug Interactions - Streptomycin
Streptomycin Side Effects, and Drug Interactions - Streptomycin
SIDE EFFECTS
The following reactions are common: vestibular ototoxicity (nausea, vomiting,
and vertigo); paresthesia of face; rash; fever; urticaria; angioneurotic edema;
and eosinophilia.
The following reactions are less frequent: cochlear ototoxicity (deafness);
exfoliative dermatitis; anaphylaxis; azotemia; leucopenia; thrombocytopenia,
pancytopenia; hemolytic anemia; muscular weakness; and amblyopia.
Vestibular dysfunction resulting from the parenteral administration of streptomycin
is cumulatively related to the total daily dose. When 1.8 to 2 g/day are given,
symptoms are likely to develop in the large percentage of patients especially
in the elderly or patients with impaired renal function within four weeks.
Therefore, it is recommended that caloric and audiometric tests be done prior
to, during, and following intensive therapy with streptomycin in order to facilitate
detection of any vestibular dysfunction and/or impairment of hearing which may
occur.
Vestibular symptoms generally appear early and usually are reversible with
early detection and cessation of streptomycin administration. Two to three months
after stopping the drug, gross vestibular symptoms usually disappear, except
for the relative inability to walk in total darkness or on very rough terrain.
Although streptomycin is the least nephrotoxic of the aminoglycosides, nephrotoxicity
does occur rarely.
Clinical judgment as to termination of therapy must be exercised when side
effects occur.
DRUG INTERACTIONS
The ototoxic effects of the aminoglycosides, including streptomycin, are potentiated by the co-administration of ethacrynic
acid, furosemide, mannitol and possibly other diuretics.
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