A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Winstrol Pharmacology, Pharmacokinetics, Studies, Metabolism - Anabolic steroids
Winstrol Pharmacology, Pharmacokinetics, Studies, Metabolism - Anabolic steroids
CLINICAL PHARMACOLOGY
Anabolic steroids are synthetic derivatives of testosterone.
Certain clinical effects and adverse reactions demonstrate the androgenic properties
of this class of drugs. Complete dissociation of anabolic and androgenic effects
has not been achieved. The actions of anabolic steroids are therefore similar
to those of male sex hormones with the possibility of causing serious disturbances
of growth and sexual development if given to young children. They suppress the
gonadotropic functions of the pituitary and may exert a direct effect upon the
testes.
WINSTROL has been found to increase low-density lipoproteins and decrease high-density
lipoproteins. These changes are not associated with any increase in total cholesterol
or triglyceride levels and revert to normal on discontinuation of treatment.
Hereditary angioedema (HAE) is an autosomal dominant disorder caused by a deficient
or nonfunctional C1 esterase inhibitor (C1 INH) and clinically characterized
by episodes of swelling of the face, extremities, genitalia, bowel wall, and
upper respiratory tract.
In small scale clinical studies, stanozolol was effective in controlling the
frequency and severity of attacks of angioedema and in increasing serum levels
of C1 INH and C4. WINSTROL is not effective in stopping HAE attacks while they
are under way. The effect of WINSTROL on increasing serum levels of C1 INH and
C4 may be related to an increase in protein anabolism.
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