A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Sotradecol Side Effects, and Drug Interactions - Sodium Tetradecyl
Sotradecol Side Effects, and Drug Interactions - Sodium Tetradecyl
SIDE EFFECTS
Local reactions consisting of pain, urticaria or ulceration may occur at the
site of injection. A permanent discoloration, usually small and hardly noticeable
but which may be objectionable from a cosmetic viewpoint, may remain along the
path of the sclerosed vein segment. Sloughing and necrosis of tissue may occur
following extravasation of the drug.
Allergic reactions such as hives, asthma, hayfever and anaphylactic shock have
been reported. Mild systemic reactions that have been reported include headache,
nausea and vomiting. (See WARNINGS .)
Four deaths have been reported with the use of Sotradecol®. One death has been
reported in a patient who received Sotradecol® and who had been receiving an
antiovulatory agent. Another death (fatal pulmonary embolism) has been reported
in a 36-year-old female treated with sodium tetradecyl acetate and who
was not taking oral contraceptives. Two cases of anaphylactic shock leading
to death have been reported in patients who received Sotradecol®. One of the
patients reported a medical history of asthma, a contraindication to the administration
of Sotradecol®.
DRUG INTERACTIONS
No well-controlled studies have been performed on patients taking antiovulatory
agents. The physician must use judgment and evaluate any patient taking antiovulatory
drugs prior to initiating treatment with Sotradecol®. (See SIDE EFFECTS
.)
Heparin should not be included in the same syringe as Sotradecol®, since the
two are incompatible.
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