A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Sod Bicarbonate Side Effects, and Drug Interactions - Sodium Bicarbonate
Sod Bicarbonate Side Effects, and Drug Interactions - Sodium Bicarbonate
SIDE EFFECTS
Overly aggressive therapy
with Sodium Bicarbonate Injection, USP can result in metabolic alkalosis
(associated with muscular
twitchings, irritability and tetany) and hypernatremia.
Inadvertent extravasation
of intravenously administered hypertonic
solutions of sodium bicarbonate
have been reported to cause
chemical cellulitis
because of their alkalinity, with tissue
necrosis, ulceration
or sloughing at the
site of infiltration. Prompt elevation
of the part, warmth and local
injection of lidocaine
or hyaluronidase
are recommended to prevent sloughing
of extravasated I.V. infusions.
DRUG INTERACTIONS
Additives may be incompatible; norepinephrine
and dobutamine are incompatible with sodium
bicarbonate solution.
The addition of sodium
bicarbonate to parenteral
solutions containing calcium should be avoided, except where compatibility
has been previously established. Precipitation or haze may result
from sodium bicarbonate-calcium
admixtures.
NOTE: Do not use the injection
if it contains precipitate. Additives may be incompatible. Consult
with pharmacist, if available. When introducing additives, use aseptic
technique, mix thoroughly
and do not store.
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