Rapamune Overdose, Contraindications and Information - Sirolimus

Rapamune Overdose, Contraindications and Information - Sirolimus

OVERDOSE

There is minimal experience with overdose. During clinical trials, there were two accidental Rapamune ingestions, of 120 mg and 150 mg. One patient, receiving 150 mg, experienced an episode of transient atrial fibrillation. The other patient experienced no adverse effects. General supportive measures should be followed in all cases of overdose. Based on the poor aqueous solubility and high erythrocyte binding of Rapamune, it is anticipated that Rapamune is not dialyzable to any significant extent. In mice and rats, the acute oral lethal dose was greater than 800 mg/kg.

Rapamune is contraindicated in patients with a hypersensitivity to sirolimus or its derivatives or any component of the drug product.