A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Disalcid Side Effects, and Drug Interactions - Salsalate
Disalcid Side Effects, and Drug Interactions - Salsalate
SIDE EFFECTS
In two well-controlled clinical
trials (n= 280 patients), the following reversible adverse experiences
characteristic
of salicylates were most commonly reported with DISALCID, listed
in descending order of
frequency: tinnitus, nausea,
hearing impairment,
rash, and vertigo. These
common symptoms of salicylates, i.e., tinnitus
or reversible hearing
impairment, are often
used as a guide to therapy.
Although cause-and-effect relationships have not been established,
spontaneous reports over a tenyear period
have included the following additional medically significant adverse
experiences: abdominal
pain, abnormal
hepatic function, anaphylactic
shock, angioedema,
bronchospasm, decreased
creatinine dearance,
diarrhea, G.I. bleeding,
hepatitis, hypotension,
nephritis and urticaria.
DRUG ABUSE AND DEPENDENCE
Drug abuse and dependence
have not been reported with DISALCID.
DRUG INTERACTIONS
Salicylates antagonize the uricosuric
action of . drugs used
to treat gout. ASPIRIN AND OTHER SALICYLATE DRUGS WILL BE ADDITIVE
TO DISALCID AND MAY INCREASE
PLASMA CONCENTRATIONS OF SALICYLIC ACID
TO TOXIC LEVELS. Drugs
and foods that raise urine
pH will
increase renal clearance
and urinary excretion of salicylic acid,
thus lowering plasma
levels; acidifying drugs or foods will
decrease urinary excretion
and increase plasma levels.
Salicylates given concomitantly with anticoagulant
drugs may predispose to systemic bleeding. Salicylates may enhance
the hypoglycemic effect
of oral antidiabetic drugs
of the sulfonylurea
class. Salicylate competes with a number
of drugs for protein
binding sites, notably penicillin, thiopental, thyroxine, triiodothyronine,
phenytoin, sulfinpyrazone, naproxen, warfarin, methotrexate, and
possibly corticosteroids.
Drug/ Laboratory Test Interactions
Salicylate competes with thyroid
hormone for binding
to plasma proteins, which
may be reflected in a depressed
plasmaT value in some
patients; thyroid function and basal
metabolism are unaffected.
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