Requip Overdose, Contraindications and Information - Ropinirole

Requip Overdose, Contraindications and Information - Ropinirole

OVERDOSE

There were no reports of intentional overdose of Requip in the premarketing clinical trials. A total of 27 patients accidentally took more than their prescribed dose of Requip , with 10 patients ingesting more than 24 mg/day. The largest overdose reported in premarketing clinical trials was 435 mg taken over a 7-day period (62.1 mg/day). Of patients who received a dose greater than 24 mg/day, one experienced mild oro-facial dyskinesia, another patient experienced intermittent nausea. Other symptoms reported with accidental overdoses were: agitation, increased dyskinesia, grogginess, sedation, orthostatic hypotension, chest pain, confusion, vomiting and nausea.

Overdose Management

It is anticipated that the symptoms of Requip overdose will be related to its dopaminergic activity. General supportive measures are recommended. Vital signs should be maintained, if necessary. Removal of any unabsorbed material (e.g., by gastric lavage) should be considered.

Requip is contraindicated for patients known to have hypersensitivity to the product.