A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Quixin Online, Description, Chemistry, Ingredients - Levofloxacin
Quixin Online, Description, Chemistry, Ingredients - Levofloxacin
DESCRIPTION
QUIXIN™ (levofloxacin ophthalmic solution) 0.5% is a sterile topical ophthalmic
solution. Levofloxacin is a fluoroquinolone antibacterial active against a broad
spectrum of Gram-positive and Gram-negative ocular pathogens. Levofloxacin is
the pure (-)-(S)-enantiomer of the racemic drug substance, ofloxacin. It is
more soluble in water at neutral pH than ofloxacin. C 18 H 20
FN 3 O 4 · 1 / 2 H 2
O Mol Wt 370.38. The structural formula is:
Chemical name: (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7
H -pyrido[1,2,3- de ]-1,4 benzoxazine-6-carboxylic acid hemihydrate.
Levofloxacin (hemihydrate) is a yellowish-white crystalline powder.
Each mL of QUIXIN™ contains 5.12 mg of levofloxacin hemihydrate equivalent
to 5 mg levofloxacin.
Contains: Active: Levofloxacin 0.5% (5 mg/mL); Preservative: benzalkonium
chloride 0.005%; Inactives: sodium chloride and water. May also contain
hydrochloric acid and/or sodium hydroxide to adjust pH.
QUIXIN™ solution is isotonic and formulated at pH 6.5 with an osmolality of
approximately 300 mOsm/kg. Levofloxacin is a fluorinated 4-quinolone containing
a six-member (pyridobenzoxazine) ring from positions 1 to 8 of the basic ring
structure.
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