A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Daraprim Side Effects, and Drug Interactions - Pyrimethamine
Daraprim Side Effects, and Drug Interactions - Pyrimethamine
SIDE EFFECTS
Hypersensitivity reactions, occasionally severe (such as Stevens-Johnson
syndrome, toxic epidermal necrolysis, erythema multiforme, and anaphylaxis),
and hyperpheny-lalaninemia, can occur particularly when pyrimethamine is administered
concomitantly with a sulfonamide. Consult the complete prescribing information
for the relevant sulfonamide for sulfonamide-associated adverse events. With
doses of pyrimethamine used for the treatment of toxoplasmosis, anorexia and
vomiting may occur. Vomiting may be minimized by giving the medication with
meals; it usually disappears promptly upon reduction of dosage. Doses used in
toxoplasmosis may produce megaloblastic anemia, leukopenia, thrombocytopenia,
pancytopenia, atrophic glossitis, hematuria, and disorders of cardiac rhythm.
Hematologic effects, however, may also occur at low doses in certain individuals
(see PRECAUTIONS: General).
Pulmonary eosinophilia has been reported rarely.
DRUG INTERACTIONS
Pyrimethamine may be used with sulfonamides, quinine and other
antimalarials, and with other antibiotics. However, the concomitant use of other
antifolic drugs or agents associated with myelosuppression including sulfon-amides
or trimethoprim-sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic
agents (e.g., methotrex-ate) while the patient is receiving pyrimethamine, may
increase the risk of bone marrow suppression. If signs of folate deficiency
develop, pyrimethamine should be discontinued. Folinic acid (leucovorin) should
be administered until normal hematopoiesis is restored (see WARNINGS).
Mild hepatotoxicity has been reported in some patients when lorazepam and pyrimethamine
were administered concomitantly.
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