A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Prosed Side Effects, and Drug Interactions - Methenamine, Salicylate, Methylene Blue, Benzoic Acid Atropine and Hyoscyamine
Prosed Side Effects, and Drug Interactions - Methenamine, Salicylate, Methylene Blue, Benzoic Acid Atropine and Hyoscyamine
SIDE EFFECTS
Cardiovascular rapid pulse, flushing
Central Nervous System blurred vision, dizziness
Respiratory shortness of breath or troubled breathing
Genitourinary difficult micturition, acute urinary retention
Gastrointestinal dry mouth, nausea/vomiting.
DRUG ABUSE AND DEPENDENCE
A dependence on the use of PROSED®/DS has not been reported and due
to the nature of its ingredients, abuse of PROSED®/DS is not expected.
DRUG INTERACTIONS
As a result of atropine's and hyoscamine's effects on gastrointestinal motility and gastric emptying, absorption of other
oral medications may be decreased during concurrent use with this combination
medication. Urinary alkalizers and thiazide diuretics: May cause the urine to
become alkaline reducing the effectiveness of methenamine by inhibiting its
conversion to formaldehyde.
Antimuscarinics: Concurrent use may intensify antimuscarinic effects of atropine
and hyoscyamine because of secondary antimuscarinic activities of these medications.
Antacids/antidiarrheals: Concurrent use may reduce absorption of atropine and
hyoscyamine resulting in decreased therapeutic effectiveness. Concurrent use
with antacids may cause urine to become alkaline reducing the effectiveness
of methenamine by inhibiting its conversion to formaldehyde. Doses of these
medications should be spaced 1 hour apart from doses of atropine and hyoscyamine.
Antimyasthenics: Concurrent use with atropine and hyoscyamine may further reduce
intestinal motility, therefore, caution is recommended.
Ketoconazole-atropine and hyoscyamine may cause increased gastrointestinal
pH. Concurrent administration with atropine and hyoscyamine may result in marked
reduction in the absorption of ketoconazole. Patients should be advised to take
this combination at least 2 hours after ketoconazole.
Monoamine oxidase (MAO) inhibitors: Concurrent use with atropine and hyoscyamine
may intensify antimuscarinic side effects.
Opioid (narcotic) analgesics may result in increased risk of severe constipation.
Sulfonamides: These drugs may precipitate with formaldehyde in the urine increasing
the danger of crystalluria.
Patients should be advised that the urine and/or stools may become blue to
blue-green as a result of the excretion of methylene blue.
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