A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Actos Online, Description, Chemistry, Ingredients - Pioglitazone hydrochloride
Actos Online, Description, Chemistry, Ingredients - Pioglitazone hydrochloride
ACTOS®
(pioglitazone hydrochloride) Tablets
DESCRIPTION
ACTOS (pioglitazone hydrochloride) is an oral antidiabetic
agent that acts primarily by decreasing insulin resistance. ACTOS is used in
the management of type 2 diabetes mellitus (also known as non-insulin-dependent
diabetes mellitus [NIDDM] or adult-onset diabetes). Pharmacological studies
indicate that ACTOS improves sensitivity to insulin in muscle and adipose tissue
and inhibits hepatic gluconeogenesis. ACTOS improves glycemic control while
reducing circulating insulin levels.
Pioglitazone[(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-]
thiazolidine-dione monohydrochloride belongs to a different chemical class and
has a different pharmacological action than the sulfonylureas, metformin, or
the a-glucosidase inhibitors. The molecule contains
one asymmetric carbon, and the compound is synthesized and used as the
racemic mixture. The two enantiomers of pioglitazone interconvert in vivo.
No differences were found in the pharmacologic activity between the two
enantiomers. The structural formula is as shown:
Pioglitazone hydrochloride is an odorless white crystalline
powder that has a molecular formula of C19H20N2O3S•HCl
and a molecular weight of 392.90 daltons. It is soluble in
N,N-dimethylformamide, slightly soluble in anhydrous ethanol,
very slightly soluble in acetone and acetonitrile, practically insoluble in
water, and insoluble in ether. ACTOS is available as a tablet for oral administration
containing 15 mg, 30 mg, or 45 mg of pioglitazone (as the base) formulated with
the following excipients: lactose monohydrate NF, hydroxypropylcellulose NF,
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