A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Pediatric Gentamicin Side Effects, and Drug Interactions - Pediatric Gentamicin
Pediatric Gentamicin Side Effects, and Drug Interactions - Pediatric Gentamicin
SIDE EFFECTS
Nephrotoxicity: Adverse renal
effects, as demonstrated by the presence of casts, cells or protein
in the urine or by rising
BUN, NPN, serum creatinine
or oliguria, have been
reported. They occur more frequently in patients with a history
of renal impairment
and in patients treated for longer periods or with larger dosages
than recommended.
Neurotoxicity: Serious adverse effects on both vestibular
and auditory branches
of the eighth nerve have
been reported primarily in patients with renal
impairment (especially
if dialysis is required)
and in patients on high doses and/or prolonged therapy. Symptoms
include dizziness, vertigo, tinnitus,
roaring in the ears and also hearing
loss, which, as with other aminoglycosides, may be irreversible.
Hearing loss is usually manifested initially by diminution of high-tone
acuity. Other factors which may increase the risk
of toxicity include
excessive dosage, dehydration and previous exposure
to other ototoxic drugs.
Numbness, skin tingling,
muscle twitching
and convulsions have also been reported.
Note: The risk
of toxic reactions is
low in neonates, infants and children with normal
renal function
who do not receive Pediatric Gentamicin Sulfate Injection at higher
doses or for longer periods of time
than recommended.
Other reported adverse reactions possibly related to gentamicin
include: respiratory depression,
lethargy, confusion,
depression, visual
disturbances, decreased appetite, weight
loss, and hypotension
and hypertension; rash, itching, urticaria,
generalized burning, laryngeal
edema, anaphylactoid reactions,
fever, and headache; nausea,
vomiting increased
salivation and stomatitis;
purpura, pseudotumor
cerebri, acute organic
brain syndrome, pulmonary
fibrosis, alopecia,
joint pain,
transient hepatomegaly,
and splenomegaly.
Laboratory abnormalities possibly related to gentamicin
include: increased levels of serum
transaminase, (SGOT, SGPT), serum
LDH and bilirubin; decreased
serum calcium, magnesium,
sodium and potassium;
anemia, leukopenia
granulocytopenia, transient agranulocytosis,
eosinophilia, increased
and decreased reticulocyte counts, and thrombocytopenia.
While local tolerance
of Pediatric Gentamicin Sulfate Injection is generally excellent,
there has been an occasional report
of pain at the injection
site. Subcutaneous atrophy
or fat necrosis
suggesting local irritation
has been reported rarely.
DRUG INTERACTIONS
No information provided.
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