A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Paser Online, Description, Chemistry, Ingredients - Aminosalicylic Acid
Paser Online, Description, Chemistry, Ingredients - Aminosalicylic Acid
DESCRIPTION
PASER granules are a delayed release granule preparation of aminosalicylic
acid (p-aminosalicylic acid: 4-aminosalicylic acid) for use with other anti-tuberculosis
drugs for the treatment of all forms of active tuberculosis due to susceptible
strains of tubercle bacilli. The granules are designed for gradual release to
avoid high peak levels not useful (and perhaps toxic) with bacteriostatic drugs.
Aminosalicylic acid is rapidly degraded in acid media; the protective acid-resistant
outer coating is rapidly dissolved in neutral media so a mildly acidic food
such as orange, apple or tomato juice, yogurt or apple sauce should be used.
Aminosalicylic acid (p-aminosalicylic acid) is 4-Amino-2-hydroxybenzoic acid.
PASER granules are the free base of aminosalicylic acid and do NOT contain sodium
or a sugar. The molecular formula is C 7 H 7 NO 3
with a molecular weight of 153.14. With heat p-aminosalicylic acid is
decarboxylated to produce CO 2 and m-aminophenol. If the airtight
packets are swollen, storage has been improper. DO NOT USE if packets are swollen
or the granules have lost their tan color and are dark brown or purple.
PASAR granules are supplied as off-white tan colored granules with an average
diameter of 1.5 mm and an average content of 60% aminosalicylic acid by weight.
The acid resistant outer coating will be completely removed by a few minutes
at a neutral pH. The inert ingredients are:
colloidal silicon dioxide
dibutyl sebacate
hydroxypropyl methyl cellulose
methacrylic acid copolymer
microcystalline cellulose
talc
The packets contain 4 grams of aminosalicylic acid for oral administration
three times a day by sprinkling an apple sauce or yogurt to be eaten without
chewing. Suspension in an acidic fruit drink such as orange juice or tomato
juice will protect the coating for at least 2 hours. Swirling the juice in the
glass will help resuspend the granules if they sink.
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