A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Roxicodone Overdose, Contraindications and Information - Oxycodone
Roxicodone Overdose, Contraindications and Information - Oxycodone
OVERDOSE
Signs and Symptoms:Serious overdose
of oxycodone hydrochloride is characterized by respiratory
depression (a decrease
in respiratory rate
and/or tidal volume, Cheyne-Stokes
respiration, cyanosis),
extreme somnolence progressing to stupor
or coma, skeletal
muscle flaccidity, cold
and clammy skin, and sometimes bradycardia
and hypotension. In
severe overdosage, apnea, circulatory
collapse, cardiac arrest
and death may occur.
Treatment: Primary attention
should be given to the reestablishment of adequate respiratory
exchange through provision
of a patent airway
and the institution of assisted or controlled ventilation. The narcotic
antagonist naloxone is a specific
antidote against respiratory
depression which
may result from overdosage or unusual sensitivity
to narcotics, including oxycodone. Therefore, an appropriate
dose of naloxone (usual
initial adult
dose: 0.4 mg) should be administered, preferably by the intravenous
route, simultaneously with efforts at respiratory
resuscitation. Since the duration
of action of oxycodone may exceed that of the antagonist, the patient
should be kept under continued surveillance
and repeated doses of the antagonist
should be administered as needed to maintain adequate respiration.
An antagonist should
not be administered in the absence
of clinically significant respiratory
or cardiovascular
depression.
Oxygen, intravenous
fluids, vasopressors and other supportive measures should be employed
as indicated.
Gastric emptying may be useful in removing unabsorbed drug.
CONTRAINDICATIONS
Hypersensitivity to oxycodone.
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