A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Ortho-Evra Online, Description, Chemistry, Ingredients - Norelgestromin and Ethinyl Estradiol
Ortho-Evra Online, Description, Chemistry, Ingredients - Norelgestromin and Ethinyl Estradiol
DESCRIPTION
Patients should be counseled that this product does not protect against HIV
infection (AIDS) and other sexually transmitted diseases.
Rx Only
ORTHO EVRA™ is a combination transdermal contraceptive patch
with a contact surface area of 20 cm2. It contains 6.00 mg norelgestromin
and 0.75 mg ethinyl estradiol (EE), and releases 150 micrograms of norelgestromin
and 20 micrograms of EE to the bloodstream per 24 hours.
ORTHO EVRA™ is a thin, matrix-type transdermal contraceptive patch consisting
of three layers. The backing layer is composed of a beige flexible film consisting
of a low-density pigmented polyethylene outer layer and a polyester inner layer.
It provides structural support and protects the middle adhesive layer from the
environment. The middle layer contains polyisobutylene/polybutene adhesive,
crospovidone, non-woven polyester fabric and lauryl lactate as inactive components.
The active components in this layer are the hormones, norelgestromin and ethinyl
estradiol. The third layer is the release liner, which protects the adhesive
layer during storage and is removed just prior to application. It is a transparent
polyethylene terephthalate (PET) film with a polydimethylsiloxane coating on
the side that is in contact with the middle adhesive layer. The outside of the
backing layer is heat-stamped "ORTHO EVRA™ 150/20."
Molecular weight, norelgestromin: 327.47
Molecular weight, ethinyl estradiol: 296.41
Chemical name for norelgestromin: 18, 19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-
17-hydroxy-, 3-oxime, (17 α ) Chemical name for ethinyl estradiol: 19-Norpregna-1,
3, 5 (10)-trien-20-yne-3, 17-diol, (17 α )
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