Chibroxin Online, Description, Chemistry, Ingredients - Norfloxacin

Chibroxin Online, Description, Chemistry, Ingredients - Norfloxacin

DESCRIPTION

CHIBROXIN® (norfloxacin ophthalmic solution) is a synthetic broad-spectrum antibacterial agent supplied as a sterile isotonic solution for topical ophthalmic use. Norfloxacin, a fluoroquinolone, is 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl) -3- quinoline-carboxylic acid. Its empirical formula is C ₁₆ H ₁₈ FN ₃ O _3.

Norfloxacin is a white to pale yellow crystalline powder with a molecular weight of 319.34 and a melting point of about 221°C. It is freely soluble in glacial acetic acid and very slightly soluble in ethanol, methanol and water.

CHIBROXIN Ophthalmic Solution 0.3% is supplied as a sterile isotonic solution. Each mL contains 3 mg norfloxacin. Inactive ingredients: disodium edetate, sodium acetate, sodium chloride, hydrochloric acid (to adjust pH) and water for injection, Benzalkonium chloride 0.0025% is added as preservative. The pH of CHIBROXIN is approximately 5.2 and the osmolarity is approximately 285 m0smol/liter.

Norfloxacin, a fluoroquinolone, differs from quinolones by having a fluorine atom at the 6 position and a piperazine moiety at the 7 position.