A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Neodecadron Pharmacology, Pharmacokinetics, Studies, Metabolism - Neomycin and Dexamethasone
Neodecadron Pharmacology, Pharmacokinetics, Studies, Metabolism - Neomycin and Dexamethasone
CLINICAL PHARMACOLOGY
Corticosteroids suppress the inflammatory response to a variety of agents,
and they probably delay or slow healing. Since corticosteroids may inhibit the
body's defense mechanism against infection, a concomitant antimicrobial drug
may be used when this inhibition is considered to be clinically significant
in a particular case.
When a decision to administer both a corticosteroid and an antimicrobial is
made, the administration of such drugs in combination has the advantage of greater
patient compliance and convenience, with the added assurance that the appropriate
dosage of both drugs is administered, plus assured compatibility of ingredients
when both types of drug are in the same formulation and, particularly, that
the correct volume of drug is delivered and retained.
The relative potency of corticosteroids depends on the molecular structure,
concentration, and release from the vehicle.
Microbiology
The anti-infective component in Ophthalmic Solution NEODECADRON is included
to provide action against specific organisms susceptible to it. Neomycin sulfate
is active in vitro against susceptible strains of the following microorganisms:
Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter
species, and Neisseria species. The product does not provide adequate
coverage against: Pseudomonas aeruginosa, Serratia marcescens , and streptococci,
including Streptococcus pneumoniae . (See INDICATIONS AND USAGE.)
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