A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Neodecadron Online, Description, Chemistry, Ingredients - Neomycin and Dexamethasone
Neodecadron Online, Description, Chemistry, Ingredients - Neomycin and Dexamethasone
DESCRIPTION
Ophthalmic Solution NEODECADRON™ (Neomycin Sulfate-Dexamethasone Sodium
Phosphate) is a topical corticosteroid-antibiotic solution for ophthalmic use.
Dexamethasone sodium phosphate is 9-fluoro-11(beta), 17-dihydroxy-16(alpha)-methyl-21-(phosphonooxy)pregna-1,
4-diene-3, 20-dione disodium salt. Its empirical formula is C 22 H
28 FNa 2 O 8 P.
Dexamethasone is a synthetic analog of naturally occurring glucocorticoids
(hydrocortisone and cortisone).
Dexamethasone sodium phosphate is a water soluble, inorganic ester of dexamethasone.
Its molecular weight is 516.41.
Neomycin sulfate, an antibiotic of the aminoglucoside group, is a mixture of
the sulfate salts of neomycin, produced by the growth of Streptomyces fradiae
Waksman (Fam. Stretomycetaceae). Neomycin is a complex typically containing
8-13% neomycin C, less than 0.2% neomycin A, and the rest, neomycin B. The empirical
formula for both neomycin B and neomycin C is C 23 H 46 N
6 O 13 , and the molecular weight for each is 614.65.
Neomycin A (also referred to as neamine) has an empirical formula of C 12
H 26 N 4 O 6 and a molecular weight of
322.36.
|
Neomycin B
R 1 =H, R 2 =CH 2 NH 2
|
Neomycin C
R 1 =CH 2 NH 2 , R 2
=H
|
Each milliliter of buffered Ophthalmic Solution NEODECADRON in the OCUMETER*
ophthalmic dispenser contains: dexamethasone sodium phosphate equivalent to
1 mg (0.1%) dexamethasone phosphate, and neomycin sulfate equivalent to 3.5
mg neomycin base. Inactive ingredients: creatinine, sodium citrate, sodium borate,
polysorbate 80, disodium edetate, hydrochloric acid to adjust pH to 6.6-7.2,
and water for injection. Benzalkonium chloride 0.02% and sodium bisulfite 0.1%
added as preservatives.
top
