A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Natacyn Pharmacology, Pharmacokinetics, Studies, Metabolism - Natamycin
Natacyn Pharmacology, Pharmacokinetics, Studies, Metabolism - Natamycin
CLINICAL PHARMACOLOGY
Natamycin is a tetraene polyene
antibiotic derived from Streptomyces natalensis. It possesses in vitro
activity against a variety of yeast and filamentous fungi, including Candida,
Aspergillus, Cephalosporium, Fusarium and Penicillium. The mechanism
of action appears to be through binding of the molecule to the sterol moiety
of the fungal cell membrane. The polyenesterol complex alters the permeability
of the membrane to produce depletion of essential cellular constituents. Although
the activity against fungi is dose-related, natamycin is predominantly fungicidal.*
Natamycin is not effective in vitro against gram-positive or gram-negative
bacteria. Topical administration appears to produce effective concentrations
of natamycin within the corneal stroma but not in intraocular fluid. Systemic
absorption should not be expected following topical administration of NATACYN
(natamycin ophthalmic suspension, USP) 5%. As with other polyene antibiotics,
absorption from the gastrointestinal tract is very poor. Studies in rabbits
receiving topical natamycin revealed no measurable compound in the aqueous humor
or sera, but the sensitivity of the measurement was no greater than 2 mg/mL.
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