Neggram Overdose, Contraindications and Information - Nalidixic Acid

Neggram Overdose, Contraindications and Information - Nalidixic Acid

OVERDOSE

Manifestations:   Toxic psychosis, convulsions, increased intracranial pressure, or metabolic acidosis may occur in patients taking more than the recommended dosage. Vomiting, nausea, and lethargy may also occur following overdosage.

Treatment:   Reactions are short-lived (two or three hours) because the drug is rapidly excreted. If overdosage is noted early, gastric lavage is indicated. If absorption has occurred, increased fluid administration is advisable and supportive measures such as oxygen and means of artificial respiration should be available. Although anticonvulsant therapy has not been used in the few instances of overdosage reported, it may be indicated in a severe case.

NegGram is contraindicated in patients with known hypersensitivity to nalidixic acid and in patients with a history of convulsive disorders.