A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Univasc Online, Description, Chemistry, Ingredients - Moexipril
Univasc Online, Description, Chemistry, Ingredients - Moexipril
DESCRIPTION
PREGNANCY WARNING:
ACE inhibitors should be discontinued as soon as pregnancy
is detected
(see WARNINGS).
UNIVASC® (moexipril hydrochloride), the hydrochloride
salt of moexipril, has the empirical
formula C27H34N2O7-HCl
and a molecular weight
of 535.04. It is chemically described as [3S-[2[R*(R*)],3R*]]-2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-
oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic
acid, monohydrochloride. It is a non-sulfhydryl containing precursor
of the active angiotensin-converting enzyme
(ACE) inhibitor moexiprilat. Its structual formula is:
Moexipril hydrochloride
is a fine white to off-white
powder. It is soluble (about 10% weight-to-volume) in distilled
water at room
temperature.
UNIVASC® is supplied as scored, coated tablets containing
7.5 mg and 15 mg
of moexipril hydrochloride
for oral administration.
In addition to the active ingredient, moexipril hydrochloride, the
tablet core contains the following inactive ingredients: lactose,
magnesium oxide, crospovidone,
magnesium stearate
and gelatin. The film coating
contains hydroxypropyl methylcellulose, hydroxypropyl cellulose,
polyethylene glycol
6000, magnesium stearate,
titanium dioxide, and
ferric oxide.
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