A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Metrolotion Side Effects, and Drug Interactions - Metronidazole (lotion)
Metrolotion Side Effects, and Drug Interactions - Metronidazole (lotion)
SIDE EFFECTS
In a controlled clinical
trial, safety data from 141 patients who used MetroLotion Topical
Lotion TM (n=71), or the lotion
vehicle (n=70), twice daily and experienced a local
cutaneous adverse
event which may or may not have been related to the treatments include:
local allergic reaction,
MetroLotion Topical Lotion 2 (3%), lotion
vehicle 0; contact dermatitis,
MetroLotion Topical TM Lotion 2(3%), lotion vehicle
1(1%); pruritus, MetroLotion
Topical Lotion 1(1%), lotion
vehicle TM 0; skin
discomfort (burning and stinging), MetroLotion Topical Lotion 1(1%),
lotion vehicle
TM 2(3%); erythema,
MetroLotion Topical Lotion 4(6%), lotion
vehicle 0; dry skin,
MetroLotion TM Topical Lotion 0, lotion
vehicle 1(1%); and worsening
of rosacea, MetroLotion Topical Lotion TM 1(1%), and
lotion vehicle
7 (10%).
The following additional adverse experiences have been reported
with the topical use
of metronidazole: skin
irritation, transient
redness, metallic taste, tingling or numbness
of extremities, and nausea.
DRUG INTERACTIONS
Oral metronidazole
has been reported to potentiate
the anticoagulant effect of warfarin and coumarin anticoagulants,
resulting in a prolongation of prothrombin
time. The effect of topical
metronidazole
on prothrombin time is not known.
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