Celontin Pharmacology, Pharmacokinetics, Studies, Metabolism - Methsuximide

Celontin Pharmacology, Pharmacokinetics, Studies, Metabolism - Methsuximide

CLINICAL PHARMACOLOGY

Methsuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central nervous system to convulsive stimuli.