A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Celontin Side Effects, and Drug Interactions - Methsuximide
Celontin Side Effects, and Drug Interactions - Methsuximide
SIDE EFFECTS
Gastrointestinal System: Gastrointestinal symptoms occur frequently
and have included nausea or vomiting, anorexia, diarrhea, weight loss, epigastric
and abdominal pain, and constipation.
Hemopoietic System: Hemopoietic complications associated with the administration
of methsuximide have included eosinophilia, leukopenia, monocytosis, and pancytopenia
with or without bone marrow suppression.
Nervous System: Neurologic and sensory reactions reported during therapy
with methsuximide have included drowsiness, ataxia or dizziness, irritability
and nervousness, headache, blurred vision, photophobia, hiccups, and insomnia.
Drowsiness, ataxia, and dizziness have been the most frequent side effects noted.
Psychologic abnormalities have included confusion, instability, mental slowness,
depression, hypochondriacal behavior, and aggressiveness. There have been rare
reports of psychosis, suicidal behavior, and auditory hallucinations.
Integumentary System: Dermatologic manifestations which have occurred
with the administration of methsuximide have included urticaria, Stevens-Johnson
syndrome, and pruritic erythematous rashes.
Cardiovascular: Hyperemia.
Genitourinary system: Proteinuria, microscopic hematuria
Body as a Whole: Periorbital edema.
DRUG INTERACTIONS
Since Celontin (methsuximide) may interact with concurrently administered antiepileptic
drugs, periodic serum level determinations of these drugs may be necessary (eg
methsuximide may increase the plasma concentrations of phenytoin and phenobarbital).
top
