Uvadex Side Effects, and Drug Interactions - Methoxsalen

Uvadex Side Effects, and Drug Interactions - Methoxsalen

SIDE EFFECTS

Side effects of photopheresis (UVADEX used with the UVAR Photopheresis System) were primarily related to hypotension secondary to changes in extracorporeal volume (>1%). In study C.C. 3 (UVADEX ), six serious cardiovascular adverse experiences were reported in five patients (5/51, 10%). Five of these six events were not related to photopheresis and did not interfere with the scheduled photopheresis treatments. One patient (1/51, 2%) with ischemic heart disease had an arrhythmia after the first day of photopheresis, but this had resolved by the next day. Six infections were also reported in five patients. Two of the six events were Hickman catheter infections in one patient, which did not interrupt the scheduled photopheresis. The other four infections were not related to photopheresis and did not interfere with scheduled treatments.

DRUG INTERACTIONS

See WARNINGS Section.