A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Neptazane Side Effects, and Drug Interactions - Methazolamide
Neptazane Side Effects, and Drug Interactions - Methazolamide
SIDE EFFECTS
Adverse reactions, occurring most often early in therapy,
include paresthesias, particularly a "tingling" feeling
in the extremities; hearing dysfunction or tinnitus; fatigue; malaise;
loss of appetite; taste
alteration; gastrointestinal disturbances such
as nausea, vomiting
and diarrhea; polyuria; and occasional instances of drowsiness
and confusion.
Metabolic acidosis
and electrolyte
imbalance may occur.
Transient myopia has
been reported. This condition
invariably subsides upon diminution or discontinuance of the medication.
Other occasional adverse reactions include urticaria,
melena, hernaturia, glycosuria,
hepatic insufficiency,
flaccid paralysis,
photosensitivity, convulsions, and rarely, crystalluria
and renal calculi. Also
see PATIENT INFORMATION for
possible reactions common to sulfonamide
derivatives. Fatalities have occurred, although rarely, due to severe
reactions to sulfonamides including Stevens-Johnson syndrome,
toxic epidermal necrolysis,
fulminant hepatic necrosis,
agranulocytosis,
aplastic anemia, and
other blood dyscrasias
(see WARNINGS).
DRUG INTERACTIONS
Methazolamide should be used with caution in patients on steroid
therapy because of the potential
for developing hypokalemia.
Caution is advised for patients receiving high-dose aspirin
and methazolamide concomitantly, as anorexia,
tachypnea, lethargy, coma
and death have been reported
with concomitant
use of high-dose aspirin
and carbonic anhydrase
inhibitors (see WARNINGS).
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