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Aramine Side Effects, and Drug Interactions - Metaraminol
SIDE EFFECTS
Sympathomimetic amines, including ARAMINE, may cause sinus or ventricular tachycardia, or other arrhythmias, especially in patients with myocardial infarction. (See PRECAUTIONS.)
In patients with a history of malaria, these compounds may provoke a relapse.
Abscess formation, tissue
necrosis, or sloughing
rarely may follow the use of ARAMINE. In
choosing the site of injection,
it is important to avoid those areas recognized as not suitable
for use of any pressor
agent and to discontinue
the infusion immediately
if infiltration
or thrombosis occurs.
Although the physician
may be forced by the urgent nature of the patient's condition to
choose injection sites
that are not recognized as suitable, he should, when possible, use
the preferred areas of injection. The larger veins of the antecubital
fossa or the thigh
are preferred to veins in the dorsum of the hand
or ankle veins, particularly
in patients with peripheral vascular disease,
diabetes mellitus,
Buerger's disease, or
conditions with coexistent hypercoagulability.
DRUG INTERACTIONS
ARAMINE should be used with caution in digitalized patients, since the combination of digitalis and sympathomimetic amines may cause ectopic arrhythmias.
Monoamine oxidase inhibitors or tricyclic antidepressants may potentiate the action of sympathomimetic amines. Therefore, when initiating pressor therapy in patients receiving these drugs, the initial dose should be small and given with caution. (See WARNINGS.)
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