A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Miltown Side Effects, and Drug Interactions - Meprobamate
Miltown Side Effects, and Drug Interactions - Meprobamate
SIDE EFFECTS
Central Nervous System
Drowsiness, ataxia, dizziness, slurred speech, headache, vertigo, weakness,
paresthesias, impairment of visual accommodation, euphoria, overstimulation,
paradoxical excitement, fast EEG activity.
Gastrointestinal
Nausea, vomiting, diarrhea.
Cardiovascular
Palpitations, tachycardia, various forms of arrhythmia, transient ECG changes,
syncope; also, hypotensive crises (including one fatal case).
Allergic or Idiosyncratic
Allergic or idiosyncratic reactions are usually seen within the period of the
first to fourth dose in patients having had no previous contact with the drug.
Milder reactions are characterized by an itchy, urticarial, or erythematous
maculopapular rash which may be generalized or confined to the groin. Other
reactions have included leukopenia, acute nonthrombocytopenic purpura, petechiae,
ecchymoses, eosinophilia, peripheral edema, adenopathy, fever, fixed drug eruption
with cross reaction to carisoprodol, and cross sensitivity between meprobamate/mebutamate
and meprobamate/carbromal.
More severe hypersensitivity reactions, rarely reported, include hyperpyrexia,
chills, angioneurotic edema, bronchospasm, oliguria, and anuria. Also, anaphylaxis,
erythema multiforme, exfoliative dermatitis, stomatitis, proctitis, Stevens-Johnson
syndrome, and bullous dermatitis, including one fatal case of the latter following
administration of meprobamate in combination with prednisolone.
In case of allergic or idiosyncratic reactions to meprobamate, discontinue
the drug and initiate appropriate symptomatic therapy, which may include epinephrine,
antihistamines, and in severe cases corticosteroids. In evaluating possible
allergic reactions, also consider allergy to excipients.
Hematologic
(See also Allergic or Idiosyncratic .) Agranulocytosis and aplastic
anemia have been reported. These cases rarely were fatal. Rare cases of thrombocytopenic
purpura have been reported.
Other
Exacerbation of porphyric symptoms.
DRUG INTERACTIONS
No Information Provided.
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