A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Mepergan Side Effects, and Drug Interactions - Meperidine and Promethazine
Mepergan Side Effects, and Drug Interactions - Meperidine and Promethazine
SIDE EFFECTS
The major hazards of meperidine, as with other narcotic analgesics, are respiratory
depression and, to a lesser degree, circulatory depression; respiratory arrest,
shock, and cardiac arrest have occurred.
The most frequently observed adverse reactions include light-headedness, dizziness,
sedation, nausea, vomiting, and sweating. These effects seem to be more prominent
in ambulatory patients and in those who are not experiencing severe pain. In
such individuals, lower doses are advisable. Some adverse reactions in ambulatory
patients may be alleviated if the patient lies down.
Other adverse reactions include:
CENTRAL NERVOUS SYSTEM
Euphoria, dysphoria, weakness, headache, agitation, tremor, uncoordinated muscle
movements, transient hallucinations and disorientation, visual disturbances
and, rarely, extrapyramidal reactions.
GASTROINTESTINAL
Dry mouth, constipation, biliary-tract spasm.
CARDIOVASCULAR
Flushing of the face, tachycardia, bradycardia, palpitation, faintness, syncope.
Cardiovascular effects from promethazine have been rare. Minor increases in
blood pressure and occasional mild hypotension have been reported. Venous thrombosis
at the injection site has been reported. Intra-arterial injection of Mepergan
may result in gangrene of the affected extremity (see " WARNINGS").
GENITOURINARY
Urinary retention.
ALLERGIC
Pruritus, urticaria, other skin rashes, wheal and flare over the vein with
IV injection.
Photosensitivity, although extremely rare, has been reported. Occurrence of
photosensitivity may be a contraindication to further treatment with promethazine
or related drugs.
OTHER
Pain at injection site; local tissue irritation, induration, and possible tissue
necrosis, particularly when injection is repeated at same site; antidiuretic
effect.
Patients may occasionally complain of autonomic reactions, such as dryness
of the mouth, blurring of vision and, rarely, dizziness following the use of
promethazine.
Very rare cases have been reported where patients receiving promethazine have
developed leukopenia. In one instance agranulocytosis has been reported. In
nearly every instance reported, other toxic agents known to have caused these
conditions have been associated with the administration of promethazine.
DRUG INTERACTIONS
No Information Provided.
top
