Megace Online, Description, Chemistry, Ingredients - Megestrol acetate

Progestational agents have been used beginning with the first trimester of pregnancy in an attempt to prevent habitual abortion. There is no evidence that the use of a high dose progestational agent such as MEGACE Oral Suspension during any phase of pregnancy is effective for this purpose. Furthermore, in the vast majority of women, the cause of abortion is a defective ovum, which progestational agents could not be expected to influence. In addition, the use of progestational agents, with their uterine- relaxant properties, in patients with fertilized defective ova may cause a delay in spontaneous abortion.

Several reports suggest an association between intrauterine exposure to progestational drugs in the first trimester of pregnancy and genital abnormalities in male and female fetuses. The risk of hypospadias, 5 to 8 per 1,000 male births in the general population, may be approximately doubled with exposure to these drugs. There are insufficient data to quantify the risk to exposed female fetuses. Because of increased genital abnormalities in male and female fetuses induced by some progestational drugs, it is prudent to avoid the use of MEGACE Oral Suspension during pregnancy.

If the patient is exposed to MEGACE Oral Suspension during pregnancy or if she becomes pregnant while taking this drug, she should be apprised of the potential risks to the fetus.