A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Malarone Online, Description, Chemistry, Ingredients - Atovaquone and Proguanil Hcl
Malarone Online, Description, Chemistry, Ingredients - Atovaquone and Proguanil Hcl
MALARONEÒ
(atovaquone and proguanil hydrochloride) Tablets
MALARONEÒ
(atovaquone and proguanil hydrochloride) Pediatric Tablets
DESCRIPTION
MALARONE (atovaquone and proguanil hydrochloride) is a fixed-dose combination of the antimalarial agents atovaquone and proguanil hydrochloride. The chemical name of atovaquone is trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione. Atovaquone is a yellow crystalline solid that is practically insoluble in water. It has a molecular weight of 366.84 and the molecular formula C22H19ClO3. The compound has the following structural formula:
The chemical name of proguanil hydrochloride is 1-(4-chlorophenyl)-5-isopropyl-biguanide
hydrochloride. Proguanil hydrochloride is a white crystalline solid that is
sparingly soluble in water. It has a molecular weight of 290.22 and the molecular
formula C11H16ClN5•HCl. The compound has the
following structural formula:
MALARONE Tablets and MALARONE Pediatric Tablets are for oral
administration. Each MALARONE Tablet contains 250 mg of atovaquone and 100 mg
of proguanil hydrochloride and each MALARONE Pediatric Tablet contains 62.5
mg of atovaquone and 25 mg of proguanil hydrochloride. The inactive ingredients
in both tablets are low-substituted hydroxypropyl cellulose, magnesium stearate,
microcrystalline cellulose, poloxamer 188, povidone K30, and sodium starch glycolate.
The tablet coating contains hypromellose, polyethylene glycol 400, polyethylene
glycol 8000, red iron oxide, and titanium dioxide.
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