A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Sulfamylon Side Effects, and Drug Interactions - Mafenide Acetate
Sulfamylon Side Effects, and Drug Interactions - Mafenide Acetate
SIDE EFFECTS
In the clinical setting
of severe burns, it is often difficult to distinguish between an
adverse reaction to
mafenide acetate and burn
sequelae. In a clinical
study of pediatric
patients with acute burns requiring autografts who received SULFAMYLON®
5% SOLUTION in addition
to double antibiotic
solution (DAB) wound
therapy (neomycin sulfate
40 mg and polymyxin
B 200,000 units/liter), the incidence of rash
(4.6%) and itching (2.8%) in the group
which received SULFAMYLON® 5% Solution was not different
from that experienced with DAB dressings alone (5.7% and 1.3%, respectively).
From other clinical
settings, a single case of bone
marrow depression
and a single case of an
acute attack
of porphyria have been reported following therapy
with mafenide acetate. Fatal hemolytic anemia with disseminated
intravascular
coagulation, presumably related to a glucose-6-phosphate dehydrogenase
deficiency, has been reported following therapy with mafenide acetate.
The following adverse reactions have been reported with topical
mafenide acetate therapy:
Dermatologic and Allergic: Pain or burning sensation, rash
and pruritis (often localized
to the area covered by the wound
dressing), erythema,
skin maceration
from prolonged wet dressings, facial
edema, swelling, hives,
blisters, eosinophilia.
Respiratory or Metabolic: Tachypnea, hyperventilation,
decrease in pCO2 , metabolic acidosis,
increase in serum chloride.
DRUG INTERACTIONS
No information provided.
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