A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Lotemax Side Effects, and Drug Interactions - Loteprednol Etabonate
Lotemax Side Effects, and Drug Interactions - Loteprednol Etabonate
SIDE EFFECTS
Reactions associated with ophthalmic
steroids include elevated intraocular pressure, which may be associated
with optic nerve
damage, visual acuity
and field defects, posterior
subcapsular cataract
formation, secondary ocular infection
from pathogens including herpes
simplex, and perforation of the globe where there is thinning of
the cornea or sclera.
Ocular adverse reactions occurring in 5-15% of patients treated
with loteprednol etabonate ophthalmic
suspension (0.2%-0.5%)
in clinical studies
included abnormal vision
/ blurring, burning on instillation, chemosis, discharge, dry eyes,
epiphora, foreign body
sensation, itching, injection, and photophobia. Other ocular
adverse reactions occurring in less than 5% of patients include
conjunctivitis,
corneal abnormalities, eyelid
erythema, keratoconjunctivitis, ocular
irritation / pain
/ discomfort, papillae, and uveitis. Some of these events were similar
to the underlying ocular disease being studied.
Non-ocular adverse reactions occurred in less than 1.5% of patients.
These include headache,
rhinitis and pharyngitis.
In a summation of
controlled, randomized studies of individuals treated for 28 days
or longer with loteprednol etabonate, the incidence
of significant elevation of intraocular
pressure (³10mmHg)
was 2% (15/901) among patients receiving loteprednol etabonate,
7% (11/164) among patients receiving 1% prednisolone
acetate and 0.5% (3/
583) among patients receiving placebo
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