A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Chirocaine Online, Description, Chemistry, Ingredients - Levobupivacaine
Chirocaine Online, Description, Chemistry, Ingredients - Levobupivacaine
DESCRIPTION
Chirocaine (levobupivacaine injection) contains a single enantiomer of bupivacaine
hydrochloride which is chemically described as (S)-1-butyl-2-piperidylformo-2',
6'-xylidide hydrochloride and it is related chemically and pharmacologically
to the amino amide class of local anesthetics.
Levobupivacaine hydrochloride, the S-enantiomer of bupivacaine, is a white
crystalline powder with a molecular formula of C 18 H 28 N
2 O · HCl, a molecular weight of 324.9.
The solubility of levobupivacaine hydrochloride in water is about 100 mg per
mL at 20°C, the partition coefficient (oleyl alcohol/water) is 1624 and the
pKa is 8.09. The pKa of levobupivacaine hydrochloride is the same as that of
bupivacaine hydrochloride and the partition coefficient is very similar to that
of bupivacaine hydrochloride (1565).
Chirocaine is a sterile, non-pyrogenic, colorless solution (pH 4.0-6.5) containing
levobupivacaine hydrochloride equivalent to 2.5 mg/mL, 5.0 mg/mL, and 7.5 mg/mL
of levobupivacaine, sodium chloride for isotonicity, and Water for Injection.
Sodium hydroxide and/or hydrochloric acid may have been added to adjust pH.
Chirocaine is preservative free and is available in 10 mL and 30 mL single dose
vials.
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