A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Leukeran Side Effects, and Drug Interactions - Chlorambucil
Leukeran Side Effects, and Drug Interactions - Chlorambucil
SIDE EFFECTS
Hematologic
The most common side effect
is bone marrow
suppression. Although bone marrow suppression
frequently occurs, it is usually reversible
if the chlorambucil is withdrawn early enough. However, irreversible
bone marrow
failure has been reported.
Gastrointestinal
Gastrointestinal disturbances such
as nausea and vomiting,
diarrhea, and oral ulceration
occur infrequently.
CNS
Tremors, muscular
twitching, confusion,
agitation, ataxia,
flaccid paresis, and
hallucinations have been reported as rare adverse experiences to
chlorambucil which resolve
upon discontinuation of drug. Rare, focal
and/or generalized seizures have been reported to occur in both
children and adults at both therapeutic daily doses and pulse-dosing
regimens, and in acute
overdose (see PRECAUTIONS:
General).
Dermatologic
Skin hypersensitivity
(including rare reports of skin
rash progressing to erythema
multiforme, toxic epidermal
necrolysis, and Stevens-Johnson
syndrome) has been reported (see WARNINGS).
Miscellaneous
Other reported adverse reactions include: pulmonary
fibrosis, hepatotoxicity
and jaundice, drug
fever, peripheral
neuropathy, interstitial
pneumonia, sterile cystitis,
infertility, leukemia,
and secondary malignancies
(see WARNINGS).
DRUG INTERACTIONS
There are no known drug/drug
interactions with chlorambucil.
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