A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Lantus Online, Description, Chemistry, Ingredients - Lantus - Insulin Glargine
Lantus Online, Description, Chemistry, Ingredients - Lantus - Insulin Glargine
DESCRIPTION
LANTUS® (insulin glargine [rDNA origin] injection) is a sterile solution of
insulin glargine for use as an injection. Insulin glargine is a recombinant
human insulin analog that is a long-acting (up to 24-hour duration of action),
parenteral blood-glucose-lowering agent. (See CLINICAL PHARMACOLOGY ). LANTUS
is produced by recombinant DNA technology utilizing a non-pathogenic laboratory
strain of Escherichia coli (K12) as the production organism. Insulin
glargine differs from human insulin in that the amino acid asparagine at position
A21 is replaced by glycine and two arginines are added to the C-terminus of
the B-chain. Chemically, it is 21 A -Gly-30 B a-L-Arg-30
B b-L-Arg-human insulin and has the empirical formula C 267
H 404 N 72 O 78 S 6 and a
molecular weight of 6063.
LANTUS consists of insulin glargine dissolved in a clear aqueous fluid. Each
milliliter of LANTUS (insulin glargine injection) contains 100 IU (3.6378 mg)
insulin glargine, 30 mcg zinc, 2.7 mg m-cresol, 20 mg glycerol 85%, and water
for injection. The pH is adjusted by addition of aqueous solutions of hydrochloric
acid and sodium hydroxide. LANTUS has a pH of approximately 4.
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