A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Lacrisert Warnings, Precautions, Pregnancy, Nursing, Abuse - Cellulose
Lacrisert Warnings, Precautions, Pregnancy, Nursing, Abuse - Cellulose
WARNINGS
Instructions for inserting and removing LACRISERT should be carefully followed.
PRECAUTIONS
General
If improperly placed, LACRISERT may result in corneal abrasion (see DOSAGE
AND ADMINISTRATION ).
Information for Patients
Patients should be advised to follow the instructions for using LACRISERT which
accompany the package.
Because this product may produce transient blurring of vision, patients should
be instructed to exercise caution when operating hazardous machinery or driving
a motor vehicle.
Drug Interactions
Application of hydroxypropyl cellulose ophthalmic inserts to the eyes of unanesthetized
rabbits immediately prior to or two hours before instilling pilocarpine, proparacaine
HCl (0.5%), or phenylephrine (5%) did not markedly alter the magnitude and/or
duration of the miotic, local corneal anesthetic, or mydriatic activity, respectively,
of these agents.
Under various treatment schedules, the anti-inflammatory effect of ocularly
instilled dexamethasone (0.1%) in unanesthetized rabbits with primary uveitis
was not affected by the presence of hydroxypropyl cellulose inserts.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Feeding of hydroxypropyl cellulose to rats at levels up to 5% of their diet
produced no gross or histopathologic changes or other deleterious effects.
Pediatric Use
Safety and effectiveness in pediatric patients have not been established.
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