Lacrisert Side Effects, and Drug Interactions - Cellulose

Lacrisert Side Effects, and Drug Interactions - Cellulose

SIDE EFFECTS

The following adverse reactions have been reported in patients treated with LACRISERT, but were in most instances mild and transient:

Transient blurring of vision (See PRECAUTIONS )

Ocular discomfort or irritation

Matting or stickiness of eyelashes

Photophobia

Hypersensitivity

Edema of the eyelids

Hyperemia

Application of hydroxypropyl cellulose ophthalmic inserts to the eyes of unanesthetized rabbits immediately prior to or two hours before instilling pilocarpine, proparacaine HCl (0.5%), or phenylephrine (5%) did not markedly alter the magnitude and/or duration of the miotic, local corneal anesthetic, or mydriatic activity, respectively, of these agents.

Under various treatment schedules, the anti-inflammatory effect of ocularly instilled dexamethasone (0.1%) in unanesthetized rabbits with primary uveitis was not affected by the presence of hydroxypropyl cellulose inserts.