A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Trandate Overdose, Contraindications and Information - Labetalol
Trandate Overdose, Contraindications and Information - Labetalol
OVERDOSE
Overdosage with labetalol HCl causes excessive hypotension
that is posture sensitive and
sometimes, excessive bradycardia. Patients should be placed supine
and their legs raised
if necessary to improve the blood
supply to the brain. If overdosage with labetalol HCl follows oral
ingestion, gastric
lavage or pharmacologically induced
emesis (using syrup
of ipecac) may be useful for removal of the drug
shortly after ingestion. The following additional measures should
be employed if necessary:
Excessive bradycardia: administer atropine or epinephrine.
Cardiac failure: administer a digitalis
glycoside and a diuretic.
Dopamine or dobutamine may also be useful.
Hypotension: administer vasopressors, e.g., norepinephrine.
There is pharmacologic evidence
that norepinephrine
may be the drug of choice.
Bronchospasm: administer epinephrine
and/or an aerosolized beta2 -agonist.
Seizures: administer diazepam.
In severe beta-blocker overdose
resulting in hypotension
and/or bradycardia, glucagon has been shown to be effective when
administered in large doses (5 to 10 mg
rapidly over 30 seconds, followed by continuous infusion
of 5 mg per
hour that can be reduced as the patient
improves).
Neither hemodialysis
nor peritoneal dialysis
removes a significant
amount of labetalol HCl from the general circulation
(<1%).
The oral LD
50
value of labetalol HCl in the mouse
is approximately 600 mg/kg and in the rat is >2 g/kg. The IV
LD
50 in these species
is 50 to 60 mg/kg.
CONTRAINDICATIONS
TRANDATE Tablets are contraindicated in bronchial
asthma, overt cardiac
failure, greater-than-first-degree heart
block, cardiogenic
shock, severe bradycardia, other conditions associated with severe
and prolonged hypotension, and in patients with a history
of hypersensitivity
to any component of
the product (see WARNINGS
).
Beta-blockers, even those with apparent
cardioselectivity, should not be used in patients with a history
of obstructive airway
disease, including asthma.
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