A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Isordil Side Effects, and Drug Interactions - Isosorbide
Isordil Side Effects, and Drug Interactions - Isosorbide
SIDE EFFECTS
Adverse reactions to isosorbide dinitrate are generally doserelated,
and almost all of these reactions are the result of isosorbide dinitrate's
activity as a vasodilator. Headache, which may be severe, is the
most commonly reported side
effect. Headache may be recurrent with each daily dose, especially
at higher doses. Transient episodes of lightheadedness, occasionally
related to blood pressure
changes, may also occur. Hypotension occurs infrequently, but in
some patients it may be severe enough to warrant discontinuation
of therapy. Syncope, crescendo angina,
and rebound hypertension
have been reported but are uncommon.
Extremely rarely, ordinary doses of organic
nitrates have caused methemoglobinemia in normal- seeming patients.
Methemoglobinemia is so infrequent at these doses that further discussion
of its diagnosis and
treatment is deferred
(see OVERDOSAGE).
Data are not available to allow estimation of the frequency
of adverse reactions during treatment
with isosorbide dinitrate tablets.
DRUG INTERACTIONS
The vasodilating effects of isosorbide dinitrate may be additive
with those of other vasodilators. Alcohol, in particular, has been
found to exhibit additive
effects of this variety.
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