A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Idamycin Online, Description, Chemistry, Ingredients - Idarubicin
Idamycin Online, Description, Chemistry, Ingredients - Idarubicin
DESCRIPTION
WARNINGS
- IDAMYCIN PFS Injection should be given slowly into a freely flowing
intravenous infusion. It must never be given intramuscularly
or subcutaneously. Severe local tissue necrosis can occur if there is
extravasation during administration.
- As is the case with other anthracyclines the use of IDAMYCIN PFS can
cause myocardial toxicity leading to congestive heart failure. Cardiac
toxicity is more common in patients who have received prior anthracyclines
or who have pre-existing cardiac disease.
- As is usual with antileukemic agents, severe myelosuppression occurs
when IDAMYCIN PFS is used at effective therapeutic doses.
- It is recommended that IDAMYCIN PFS be administered only under the
supervision of a physician who is experienced in leukemia chemotherapy
and in facilities with laboratory and supportive resources adequate
to monitor drug tolerance and protect and maintain a patient compromised
by drug toxicity. The physician and institution must be capable of responding
rapidly and completely to severe hemorrhagic conditions and/or overwhelming
infection.
- Dosage should be reduced in patients with impaired hepatic or renal
function. (See DOSAGE AND ADMINISTRATION.)
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IDAMYCIN PFS Injection contains idarubicin hydrochloride and is a sterile,
semi-synthetic, preservative-free solution (PFS) antineoplastic anthracycline
for intravenous use. Chemically, idarubicin hydrochloride is 5, 12-Naphthacenedione,
9-acetyl-7-[(3-amino-2,3,6-trideoxy-(alpha)-L- lyxo -hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxyhydrochloride,
(7S- cis ).
IDAMYCIN PFS is a sterile, red-orange, isotonic parenteral preservative-free
solution, available in 5 mL (5 mg), 10 mL (10 mg) and 20 mL (20 mg) single use
only vials.
Each mL contains Idarubicin HCl, USP 1 mg and the following inactive ingredients:
Glycerin, USP 25 mg and Water for Injection, USP q.s. Hydrochloric Acid, NF
is used to adjust the pH to a target of 3.5.
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