A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Panhematin Online, Description, Chemistry, Ingredients - Hemin
Panhematin Online, Description, Chemistry, Ingredients - Hemin
DESCRIPTION
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PANHEMATIN (hemin for injection) should only be used by physicians experienced
in the management of porphyrias in hospitals where the recommended clinical
and laboratory diagnostic and monitoring techniques are available.
PANHEMATIN therapy should be considered after an appropriate period of
alternate therapy (i.e., 400 g glucose/day for 1 to 2 days). (See "WARNINGS
", "PRECAUTIONS" and "DOSAGE AND ADMINISTRATION" sections.)
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PANHEMATIN (hemin for injection) is an enzyme inhibitor derived from processed
red blood cells. Hemin for injection was known previously as hematin. The term
hematin has been used to describe the chemical reaction product of hemin and
sodium carbonate solution. Hemin is an iron containing metalloporphyrin. Chemically
hemin is represented as chloro [ 7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato
(2-)-N 21 ,N 22 , N 23 , N 24 ]
iron.
PANHEMATIN is a sterile, lyophilized powder suitable for intravenous administration
after reconstitution. Each dispensing vial of PANHEMATIN contains the equivalent
of 313 mg hemin, 215 mg sodium carbonate and 300 mg of sorbitol. The pH may
have been adjusted with hydrochloric acid; the product contains no preservatives.
When mixed as directed with Sterile Water for Injection, USP, each 43 mL provides
the equivalent of approximately 301 mg hematin (7 mg/mL).
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